Background :Chronic liver diseases and liver cirrhosis with resistant ascites to diuretic therapy are associated with Acute Kidney Injury (AKI). AKI is a decisive predictor factor of mortality in Hepatorenal Syndrome (HRS).

Study AIM :To evaluate the rate of AKI and its effect on cirrhotic patients' survival in one of the leading hospitals in Libya.

Method :Over two years, 122 individuals with liver cirrhosis were admitted to the Medical Department of the Tripoli Central Hospital (Jan 2015-Dec 2016). Their notes were used to collect data. In the medical outpatient clinic, all the patients were monitored, and their creatinine levels were normal. Records of serum urea, creatinine, and electrolytes were gathered, as well as demographic information.

Statistical Analysis:Data were arranged in an SPSS sheet, and descriptive and percentage analysis was done. Differences between the means of serum urea and creatinine were tested by ttest, and a P-value of ≤ 0.05 was considered statistically significant.

Results:Twenty-one patients had AKI; of those,eightpatientsprogressed from the 16 patients had creatinine > 2 mg/dl died (50%).Total death in this series was eight patients (38.1%) from those patients who had AKI died in the hospital.

Conclusion:AKI occursin advanced liver cirrhosis, leading to an increased mortality rate. AKI is a significant predictor of mortality in LC patients. Therefore, closeintensive supervision is required for cirrhotic patients with ascites, aiming to prevent AKI, reduce mortality.