Abstract 

The present study investigated the effects of cigarette smoke (CS) on the epididymal tissues
and the protective effect of Sidr honey in adult male rats. 24 adult male rats were divided into
four groups: Group 1: normal control group; Group 2:rats received Sidr honey orally (100
mg/kg b.w./d.) for 4 weeks; Group 3: rats were exposed to five lit cigarettes per day (5 times
per day) for 4 weeks; and Group 4: rats received Sidr honey orally (100 mg/kg b.w./d.) for 2
weeks, then the rats were treated with cigarette smoke generated by a machine after taking the
Sidr honey for 4 weeks. The results presented the gross morphology of the vas L deferens of
rats in the group 3was smaller than that of the other groups. Moreover, the testes in group 3
were bigger as compared to all other groups. In addition, results demonstrate the rats in group
3 showed many histopathological changes in epididymal tissues when compared with the
group 1. While the epididymal tissues from the rats in the group 4displayednearly normal
histological structure of the tubules with normal sperm density as compared to the group 3.
This study indicates that Sidr honey has a protective effect against CS-induced epididymal
damage in adult male albino rats.