Background: Arbutus pavarii; locally known as "Shmeri", is an endemic plant of Libya, it is mainly grown in El-Jabal El-Akhdar region. In traditional medicine, leaves and bark are used extensively as a remedy for gastritis, renal infections, constipation, and various of other human aliments. Furthermore, A. pavarii leaves showed some important biological activities, for example; it has hypoglycemic, antioxidant, antimicrobial, and cytotoxic activities. Moreover, previous phytochemical studies showed the presence of phenols, flavonoids, carbohydrates, glycosides, sterols, triterpenes, and tannins. Objective: The present study aimed to investigate the analgesic and anti-inflammatory activities of A. pavarii leaves extract (APLE). Methods: fresh leaves of A. pavariiwere collected on march 2021. Leaves were shad-dried, ground to a fine powder and macerated in ethanol and evaporated under reduced pressure in rotary evaporator. The crude extract was administered by oral gavage at a dose of 30%. The analgesic activity was examined by hot plat method in albino rats, and by the acetic acid induced writhing response in albino mice. The anti-inflammatory effect was evaluated by both carrageenan and formalin-induced paw oedema in rats. Results: The ethanoic extract of leaves significantly increased the mean reaction time in the hot plate test (�<0.001). Also, it significantly decreased the mean of writhes induced by acetic acid(�<0.0001). In addition, the anti-inflammatory tests by both formalin and carrageenan showed a significant decrease in the paw volume of treated rats in comparison to the control(p<0.001). Conclusion: These results indicate that ethanolic extract of A. pavarii leaves may contain bioactive component(s) that have analgesic and anti-inflammatory activities.

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