Abstract:

Stem cells (SCs) are important cells for replacement therapy diseases.The interest in the potential of neural stem cells (NSCs) for the treatment of neurodegenerative diseases and brain injuries has substantially promoted research on neural stem cell self-renewal and differentiation.The geneissrybox containing gene 2 (Sox2) has been associated with a SC phenotype that predicts for poor outcomes. Sox2 is a transcription factor that regulates embryonic stem cell pluripotency and drives commitment of airway precursor cells to basal-type and neuroendocrine cells in the developing lung. Sox2gene involved will be investigated in practical pirogue according to the expression patterns.Sox2 has been associated with a SC phenotype that predicts for poor outcomes. Subsequently, information has been compiled on the question how Sox2 in neural differentiation is controlled on the molecular level, and controlled in vivo.

 

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