Neurofibromas commonly involve peripheral nervous system but rarely involve genital organs
such as labia, clitoris, vulva, vagina and cervix.
We presenta case of isolated plexiformneurofibroma of vulva who presented as white lesion of
vulva.A tissue biopsy was done and the histopathological analysis-demonstrated a
plexiformneurofibroma withspindle shaped cells with wavy nuclei and bland nuclear chromatin.
No systemic sign of neurofibromatosis was found. Immunohistochemistry showed strong
positivity for S-100 protein which has a strong correlation with neurofibromatosis-1.
Plexiformneurofibroma may present as isolated white lesion of the vulva without any systemic
involvement in the form of neurofibromatosis. So a tissue biopsy is mandatory for definitive
diagnosis of any white lesion of the vulva.
Key Words: Vaginal Cyst, HistopathologyVulva, Plexiformneurofibroma.