The present study was undertaken to evaluate the analgesic activities of water extract of
leaves and methanolic extract of seeds of Solanum nigrum Linn in experimental animal
models. The study was carried out using Swiss albino rats (210- 290g) of female sex. The
analgesic activity of Solanum nigrum was assessed by using hot plate and tail flick method.
For the determination of analgesic effect, doses of each extract of Solanum nigrum used in the
present study were 500 mg/kg body weight (BW). Hot plate test showed a significant increase
in the mean reaction time to heat stimuli in hot plate method at 500 mg/kg BW doses
throughout the observation period in 1/2 hour, 1 hour and 2 hours after treatment, which was
comparable to the standard Ibuprofen and control group. The present study suggests that each
extract of Solanum nigrum has significant analgesic and activities.

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