Background:
Pseudomonas aeruginosa is one of the most invasive organism that causes severe tissue
damage in diabetic foot ulcers. A major problem in P. aeruginosa infection because of that it
is commonly exhibits a high degree of resistance to antimicrobial agents .To improve
appropriate antimicrobial therapy and reduce the incidence of antibiotics resistant bacteria,
information on the antibiotic susceptibility to this bacterium is urgently needed. Therefore, the
aim of this study was to isolate and determinate the antimicrobial susceptibility of the P.
aeruginosa in diabetic foot ulcers patients.
Methods: This study was carried out over the period between June 2014 to April 2015 at
Tripoli Medical Center. A total of 120 bacterial isolates were cultured onto bacteriological
media such as nutrient agar, MacConkey agar and blood agar. Identification of retrieved
bacterial isolates was done using standard diagnostic microbiological laboratory methods and
antibiogram was determined by VITEK ® 2 compact automated system.
Results: Twenty one strains of P. aeruginosa from 120 diabetic foot ulcers were detected. P.
aeruginosa isolates exhibited multidrug resistance to Ampicillin, Augmenting, Cefuroxime,
Cefoxitin, Cefazolin, Ceftriaxone, Trimethoprim/sulfamethzole, Piperacillin. However, all
isolates of P. aeruginosa were 100 % sensitive to Imipenem.
Conclusion: P. aeruginosa infections of diabetic foot ulcers patients have multi-drug
resistant. Imipenem is the empirical antibiotic of the choice.
Key words: Pseudomonas aeruginosa, diabetic foot ulcer, antibiotics resistance.

 

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