This study investigated the concentration abnormalities of serum creatinine (SCr), serum
phosphorous (SP), serum triglycerides (STg) and serum total Cholesterol (STc) in males
suffering from End-StageRenal Disease (ESRD). The serum concentration of each biochemical
was determined in 30 males with ESRD (patient group) and in 30 normal males (control group).
Except for STc, the mean concentration for all the biochemicals in the patient group was higher
than the mean of the equivalent biochemical in the control group. However, the difference was
only significant in case of SCr pair and SP pair (P < 0.01). Two significant relationships (P <
0.05) were found in patient group between two pairs: SCr-SP and STg-STc. These two
relationships were not recorded in the control group. Similarly, the only significant relationship
between age and SCr (P < 0.05) found in the control group was not recorded in the patient
group. These limited differences in relationships were accompanied by limited differences in
similarity ratio according to the results of cluster analysis. The findings of this study indicate
that ESRD has a diverse effect on serum concentration of the studied biochemicals, with more
prominent impact on SCr and SP. According to the results of statistical analysis, SP can be used
in combination with SCr for early identification of ESRD.
Keywords: ESRD; creatinine; phosphorous; triglycerides; total cholesterol; t-test; correlation.