This study investigated the concentration abnormalities of serum creatinine (SCr), serum
phosphorous (SP), serum triglycerides (STg) and serum total Cholesterol (STc) in males
suffering from End-Stage Renal Disease (ESRD). The serum concentration of each
biochemical was determined in 30 males with ESRD (patient group) and in 30 normal males
(control group). Except for STc, the mean concentration for all the biochemicals in the patient
group was higher than the mean of the equivalent biochemical in the control group. However,
the difference was only significant in case of SCr pair and SP pair (P < 0.01). Two significant
relationships (P < 0.05) were found in patient group between two pairs: SCr-SP and STg-STc.
These two relationships were not recorded in the control group. Similarly, the only significant
relationship between age and SCr (P < 0.05) found in the control group was not recorded in
the patient group. These limited differences in relationships were accompanied by limited
differences in similarity ratio according to the results of cluster analysis. The findings of this
study indicate that ESRD has a diverse effect on serum concentration of the studied
biochemicals, with more prominent impact on SCr and SP. According to the results of
statistical analysis, SP can be used in combination with SCr for early identification of ESRD..
Keywords: ESRD; creatinine; phosphorous; triglycerides; total cholesterol; t-test; correlation.

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