Background: Idiopathic, non-congenital Nephrotic syndrome (NS) of childhood is
characterized by massive proteinuria and hypoalbuminemia, leading to oedema and
hypercholesterolemia. Other clinical findings, such as haematuria and hypertension, are
observed in a small fraction of patients.
Aim of this study was to identify the exact pattern of NS in Libyan children, incidence of
disease, and out-comes of NS.
This study was retrospectively carried out on 329 children (227 male and102 female), male:
female was 2.2:1, aged (mean=4.9 ±3.2 year) at the onset of the disease. All patients with
Idiopathic Nephrotic Syndrome. This diagnosis was made according to the criteria of the
international study of kidney disease in children (ISKD).
Results:
An average admission at Nephrology ward was 214 cases/ year; correspond to 5% of total
hospital admission. 30.3 % were newly diagnosed Nephrotic Syndrome (65 newly diagnosed
nephrotic patients ∕ year). Sixty nine % of children were with good sensitivity to steroid,
24.3% with steroid dependent and 6.7% were steroid resistant. Viral screen was done in 226
patients 68% ,28 children were positive for HCVAb by ELISA 8.5% of total cases,HBSAg
was positive in one female ,no one with HIV. HCVAb positive cases 78.57% of them were
steroid dependent & steroid resistant with frequent admission. The out-comes were as follow;
18 patients got hypertension, one patient with DM, two patients with hypothyroidism, one
patient with cataract and glaucoma , 8 patients were died and 135( 41.3%) got complete
remission.
Conclusion: with regular treatment and follow up, the prognosis of idiopathic Nephrotic
syndrome is good,with better organized schedules of management, has substantially reduced
the Mortality of SRNS (steroid responder Nephrotic syndrome), but death still occurs,

primarily from hypovolemia, Thrombosis and sepsis. Relapses eventually cease. Blood
pressure and renal function remain Normal.
Key words: Nephrotic Syndrome, Response to treatment, Outcome.