Helicobacter pylori (H. pylori), a microaerophilic, flagellated, curved or spiral, gram-negative
bacterium, selectively colonizes the human stomach. Its infection affected more than half of the
world’s population. It is assumed that the sequence of events in gastric cancer is as follows:
chronic gastritis, atrophy, intestinal metaplasia (IM), dysplasia, and carcinoma. It is also known
that H. pylori can be involved in the chain of these chronic phenomena.
Aim: To know the local incidence and histomorphological pattern of Helicobacter gastritis,
especially its association with intestinal metaplasia, dysplasia and malignancy in gastric biopsies.
Methods: Gastric biopsy cases were selected from database of Tripoli medical center from 2002
to 2008. The biopsies were assessed for the parameters as per revised Sydney System. The age,
gender and the microscopic findings in the gastric biopsies were tabulated and analysed.
Conclusion: Based on these results, H. pylori is a known common associated agent for chronic
gastritis with the progression of atrophy, metaplasia and dysplasia and the high bacterial load
possibly results in lymphoid proliferation.
Key wards: H. pylori, chronic gastritis, gastric carcinoma

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