Isolated polycystic liver disease is a rare condition that was not reported in Libya or North Africa
as we found when reviewing literature available on it. In this paper we present a case of a 70-
years-old Libyan male that attended Sebha Medical Center witha history of right hypochondrial
swelling and pain of three months’ duration. Oninvestigation, ultrasound showed numerous liver
cysts with no renal involvement. The following is a review of literature pertaining cystic liver
disease.