It has been well documented that there is a link between oxidative stress and
secondary complications of diabetes. In the present study we measured and
evaluated changes in levels of malondialdehyde (MDA) as marker of lipid per
oxidation and antioxidant vitamin A in plasma of Sudanese patients with Type 2
Diabetes Mellitus. Total of 200 diabetic patients (90 male, 110 female) with mean
age of 55.48±12.14 years were recruited into the study. Control group was
composed of 100 healthy volunteers (47 male, 53 female) with mean age of
53.53±11.43 years. In addition to two mentioned parameters, levels of fasting blood
glucose, percentage HbA1C levels were determined in diabetic patients and
controls.
There was a significant increase in MDA level (test group) which is used as an
indicator of metabolic stress, oxidative stress or lipid per oxidation marker. On the
other hand; antioxidant vitamin A of the test group was reduced meaningfully.
Reduction in vitamin A levels was probable due to antioxidant effect of this
antioxidant vitamin. In conclusion supplementation of antioxidant vitamin (A) into
the daily diets of diabetic patients will enhance power of non-enzymatic antioxidant
defense systems.
Keywords—Diabetes Mellitus, Vitamin A, MDA.