Post-marketing drug withdrawals can be associated with various events, ranging from safety issues such as reported deaths or severe side-effects, to a multitude of non-safety problems including lack of efﬁcacy, manufacturing, regulatory or business issues. During the last century, the majority of drugs voluntarily withdrawn from the market or prohibited by regulatory agencies was reported to be related to adverse drug reactions. Understanding the under lying mechanisms of toxicity is of utmost importance for current and future drug discovery. A questioner review about Libyan pharmacist attitude toward Zantac withdrawal in the western region of Libya. Theata then was evaluated by Microsoft Excel software for analysis.The total number of responses received was 67, and these responses were from different cities in the west of Libya during 6months study 2020. Highlighting the different sources of knowledge regarding the withdrawal decision, 64.1 % got the information through social media. 32.8 % of the pharmacists after getting the information regarding Ranitidine withdrawal returned it to the company from which bought it. 83.6% of the pharmacist when asked about ranitidine cause of drawing clarified that the ranitidine contains carcinogenic substances. 37.3% of participants mentioned that pharmacovigilance means the detection of problems related to drugs after marketing and use by patients.