Type 1 diabetes mellitus (DM) is an autoimmune disease that is characterized by inhibited insulin
production as a result of T cell-mediated destruction of the pancreatic β cells in the islets of
Langerhans. Although DM can be treated with islet transplantation which includes whole organ
transplantation, transplantation of isolated islets and regeneration therapy, a shortage of donors
limits this transplantation of islets cells. The present study will investigate for reversal of type I
diabetes. The mesenchymal stem cells from the umbilical cord will differentiate efficiently into
transplanted insulin – producing – cells in the liver that can be used to replace lost β – cells of islets of
Langerhans through portal venous transplantation through cannulation of portal vein. The way will
use for reversal of type 1 diabetes mellitus in drug induced diabetic rats.