Bleeding related to Ear, Nose and Throat surgery is a major problem in daily ENT surgical
practice. This study is done to verify the efficacy of preoperative intravenous tranexamic acid in
the control of tonsillectomy and inferior turbinectomy(IT) bleeding. Hundred cases undergoing
tonsillectomyand ITwere randomized into two groups, one of which received pre-operatively intra
venous tranexamicacid, 15 mg/kg. The other group patients were given a placebo. Amount of
bleeding was assessed in each case. The study group had statistically highly significant reduction in
bleeding. There were no side effects of the drug. This finding is similar to that in other studies for
tonsillectomy, IT and other surgeries with hemorrhagic conditions. Tranexamic acid in the dose of
15 mg /kg given intra venous pre-operatively is effective in the control of Ear, Nose and Throat
The RCPCH and NPPG Medicines Committee recommend a pragmatic dosageschedule –
15mg/kg tranexamic acid loading dose (max 1g) over 10 minutes followedby 2mg/kg per hour.

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