The serum enzymes of patients with end-stage renal disease (ESRD) are commonly abnormal.
This is due in part to the absence of renal excretion and to the frequent presence of multiple
comorbid conditions. Since the diagnosis of many diseases is based upon the detection of
elevated levels of these enzymes, the accurate clinical assessment of the patient with ESRD is
hampered by a paucity of knowledge concerning the serum concentrations of different
enzymes in various disease states. This study was conducted to essentially investigate status
of serum α-amylase in Sudanese patients of chronic renal failure (CRF) with special
reference to the effects of diabetes mellitus. A non randomly selected group of 50 patients
with chronic renal failure (31 male, 19 female) with mean age of 46 ±1.6 year, undergoing
regular haemodialysis, visiting Khartoum Renal Dialysis centre (KRDC), an Sudanese
Transplanted Kidney Association Medical center (STKA). A total number of 25 healthy
volunteered individuals as a control group (16 male, 9 female) with mean age of 37.4 ±2.5
year. Blood specimens were collected from all groups (n, 75), and level of serum α –amylase,
creatinine, urea whereas glucose were determined. Statistical analysis was done, using SPSS
package descriptive and comparing different parameters between groups of patients and
control. The study indicates a significant increase (P= 0.00) in α-amylase levels of chronic
renal failure patients when compared with control group, as a significant difference in serum
α-amylase level was similarly confirmed within subgroups of patients(diabetics & nondiabetics) and control group; the level of α-amylase in group of diabetics was less than nondiabetics group (P= 0.008). Serum α-amylase is significantly correlated with creatinine and
duration of diabetes mellitus (P= 0.31), (P= 0.008), respectively unlike blood glucose level,
age, and duration o f chronic renal failure.
Keywords—CRF, Diabetes mellitus, α-amylase