Prostate cancer is the most prevalent malignancy and the second leading cause of cancer mortality in
men. Early growth response gene-1 (Egr-1) plays a crucial role in the development and progression of
prostate cancer. We investigated the expression of Egr-1 in fifty eight cases of prostatic
adenocarcionoma and ten cases of benign prostatic hyperplasia using Immunohistochemistry technique.
Human prostate cancer specimens demonstrated higher levels of Egr-1 in malignant acini located
predominantly in the cytoplasm, with no expression in benign prostatic hyperplasia. The intensity of the
staining was positively correlated with the Gleason grading. These results show that Egr-1 is overexpressed in prostate cancer and suggest a role for Egr-1 in prostate cancer growth.