Objective :The present study was undertaken to evaluate lipid profile and urate in apparently
healthy cigarette smokers and compare it with apparently healthy non- smokers in the fasting
state. Also to demonstrate the possible effect of smoking on serum lipid profile and urate
concentration
Methods: The study was conducted on 50 healthy cigarettes smokers and compared with 50
healthy age and weight matched non-obese non-smokers who served as controls. Subjects in both
groups were in the age range of 30-60 yrs., having no history of alcohol abuse, or diseases like
diabetes mellitus, hypertension, hepatic impairment, renal disease, gout, hypouricemia, and
obesity, and were neither on drugs like β-blockers, lipid lowering drugs, or thiazide diuretics.
Clinical data were obtained from the history and record on questionnaire sheet. The clinical
assessment was done by a medical doctor.
Results: It was revealed that mean S.TC (275 ± 25 mg/dl), LDL-C (179 ± 44 mg/dl), and TG
(116 ± 29 mg/dl), were significantly higher in smokers (p <0.001) as compared to non-smokers,
i.e., mean S.TC (139 ± 25 mg/dl), LDL-C (89 ± 25), TG (93 ± 25).
mg/dl (p <0.001) as compared to non-smokers. Mean serum HDL-C (27 ± 6 mg/dl) was
significantly lower in chronic smokers (p <0.001) as compared to non-smokers, i.e., 40.0± 8
mg/dl. Mean serum Urate (5.2 ± 1.0 mg/dl) was significantly lower in chronic smokers (p
<0.001) as compared to non-smokers, i.e., 6.1. ± 1.1 mg/dl.
Conclusion: Smoking produces adverse effects on lipid profile and, therefore increasing the
cardiovascular disease risk. On the other hand the significant low level of serum urate in smokers
attributed in significant oxidative stress and hence cardiovascular disease. Cigarette smoke may
be benefit in reducing hyperuricemia risk.
Key words
S.TC : Serum Total cholesterol; LDL-C : Low density lipoprotein cholesterol; HDL-C : High
density lipoprotein cholesterol; TG : Triglycerides; urate.