The current study aims to determine the efficacy of insulin analogue on blood sugar
control in patients with type 1 diabetes mellitus, this study is a cross sectional study and was carried
out in Tripoli diabetes hospital during the period (Nov/2009-April-2010). One hundred patients
with Type 1 diabetes mellitus on basal-bolus insulin injections (after consent taken), were enrolled
in this study, insulin glargin taken as basal single dose at night (mostly at 10 pm) and Lispro
injection before each meal (3 times/day), initially the total daily requirement calculated according
to body weight or previous daily insulin doses and adjusted according to blood glucose profile done
by patients (SMBG), the results were a significant regarding increase of total daily doses and body
weight, decrease in number of hypoglycemic episodes /month and HBA1c. The study concluded
that insulin analogue (glargin & Lispro) administrations were associated with improve glycaemia
control with reduction in hypoglycemia episodes in Type-1 diabetes mellitus.
Key words: Type1 diabetes, insulin analogue, self-monitoring blood glucose